_Niemann-Pick+Disease+Types_


 * Type A appears during infancy
 * Characterized by an enlarged liver and spleen, failure to gain weight and grow, and deterioration of the nervous system
 * people with type a generally don't survive past early childhood
 * Type B ranges in features
 * Includes enlarged liver and spleen, problems growing, and problems with lung function, including frequent lung infections
 * Patients with type B usually survive into adulthood


 * Type C appears in childhood
 * Infant and adult onset is also possible
 * Signs include severe liver disease, breathing difficulties, developmental delay, seizures, poor muscle tone, lack of coordination and problems with feeding
 * Type C1 caused by a mutation in the NPC1 gene
 * Type C2 caused by a mutation in the NPC2 gene

//Genetics Home Reference//. N.p., 6 June 2011. Web. 8 June 2011. [].